Animal copy experiments have not been performed with the drug combination–promethazine and phenylephrine. It's not at all recognised whether this drug mixture could potentially cause fetal harm when administered into a Expecting female or can have an effect on copy potential. Promethazine and phenylephrine ought to be presented to the Expecting woman provided that Evidently required.
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Geriatric Use Clinical scientific tests of promethazine hydrochloride and phenylephrine hydrochloride syrup didn't involve enough quantities of topics aged 65 and around to ascertain whether or not they respond otherwise from younger topics. Other described clinical experience hasn't determined dissimilarities in responses between the elderly and young individuals.
Suggest people never to boost the dose or dosing frequency of promethazine HCl and codeine phosphate oral Option due to the fact critical adverse events like respiratory depression could take place with overdosage [see Warnings and Safeguards (5.
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Disclaimer: This content is for instructional uses only. Use Akorn solutions strictly as prescribed by a certified health-related Skilled.
Reduce Seizure Threshold: Promethazine may perhaps reduced seizure threshold. It ought to be employed with warning in persons with seizure Ailments or in persons who're applying concomitant remedies, including narcotics or area anesthetics, which may also have an impact on seizure threshold.
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Promethazine Akorn syrup is usually provided to help with coughs and indicators with the higher respiratory tract, like nasal congestion. Doctors usually suggest this syrup for older people to maintain them Harmless and obtain very good benefits.
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Promethazine is metabolized because of the liver to various compounds; the sulfoxides of promethazine and N-demethylpromethazine will be the predominant metabolites showing up inside the urine.
Sedating prescription drugs may cause confusion and over-sedation in the aged; aged clients normally really should be commenced on lower doses of promethazine hydrochloride and phenylephrine hydrochloride syrup and observed closely.